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James C Paton Selected Research

Carrier Proteins (Binding Protein)

1/2016The Variable Region of Pneumococcal Pathogenicity Island 1 Is Responsible for Unusually High Virulence of a Serotype 1 Isolate.
10/2015Multivalent Pneumococcal Protein Vaccines Comprising Pneumolysoid with Epitopes/Fragments of CbpA and/or PspA Elicit Strong and Broad Protection.
7/2002The genes encoding virulence-associated proteins and the capsule of Streptococcus pneumoniae are upregulated and differentially expressed in vivo.

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James C Paton Research Topics

Disease

54Infections
01/2021 - 04/2002
28Pneumococcal Infections
11/2021 - 07/2002
15Hemolytic-Uremic Syndrome
01/2021 - 04/2002
9Neoplasms (Cancer)
03/2022 - 11/2009
9Pneumonia (Pneumonitis)
11/2021 - 08/2003
8Inflammation (Inflammations)
01/2019 - 01/2008
7Sepsis (Septicemia)
10/2015 - 08/2003
7Necrosis
08/2013 - 07/2004
5Meningitis
01/2022 - 06/2012
5Bacterial Infections (Bacterial Infection)
01/2019 - 09/2007
5Autolysis
01/2017 - 09/2008
5Pneumococcal Pneumonia
06/2012 - 08/2003
4Hepatocellular Carcinoma (Hepatoma)
12/2018 - 08/2009
4Diarrhea
01/2016 - 08/2009
3Breast Neoplasms (Breast Cancer)
03/2022 - 01/2016
3Disease Progression
01/2022 - 06/2012
3Communicable Diseases (Infectious Diseases)
01/2021 - 08/2008
3Human Influenza (Influenza)
01/2019 - 01/2017
3Thrombosis (Thrombus)
11/2010 - 07/2004
2Ovarian Neoplasms (Ovarian Cancer)
03/2022 - 12/2019
2Acute Kidney Injury (Acute Renal Failure)
11/2019 - 01/2014
2Acute Lung Injury
01/2019 - 12/2012
2Bacterial Pneumonia
01/2019 - 11/2011
2Osteosarcoma (Osteogenic Sarcoma)
12/2018 - 11/2017
2Starvation
11/2017 - 01/2014
2Whooping Cough (Pertussis)
01/2017 - 10/2006
2Fibrosis (Cirrhosis)
07/2015 - 11/2014
2Atrophy
09/2014 - 04/2011
2Hemolytic Anemia
06/2014 - 10/2007
2Thrombocytopenia (Thrombopenia)
06/2014 - 10/2007
2Edema (Dropsy)
06/2014 - 08/2013
2Cholera
11/2013 - 10/2006
2Melanoma (Melanoma, Malignant)
09/2012 - 10/2010
2Experimental Arthritis
04/2011 - 07/2009
2Colitis
08/2009 - 01/2008
2Respiratory Tract Infections (Respiratory Tract Infection)
01/2008 - 07/2006
1Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)
10/2021
1Colorectal Neoplasms (Colorectal Cancer)
10/2021
1Acquired Immunodeficiency Syndrome (AIDS)
01/2021
1Otitis Media
01/2021
1Glioblastoma (Glioblastoma Multiforme)
01/2021

Drug/Important Bio-Agent (IBA)

27Proteins (Proteins, Gene)FDA Link
01/2022 - 04/2002
17Streptococcus pneumoniae plY proteinIBA
11/2021 - 07/2002
13Cytotoxins (Cytolysins)IBA
01/2021 - 07/2004
11Shiga Toxin (Shigella Toxin)IBA
01/2021 - 10/2007
10Endoplasmic Reticulum Chaperone BiPIBA
10/2019 - 01/2008
10VaccinesIBA
01/2019 - 08/2003
8AntigensIBA
04/2017 - 08/2003
7Virulence Factors (Pathogenicity Factors)IBA
11/2021 - 07/2004
6Anti-Bacterial Agents (Antibiotics)IBA
01/2021 - 02/2010
6CytokinesIBA
01/2020 - 07/2004
5Polysaccharides (Glycans)IBA
03/2022 - 07/2002
4Complement System Proteins (Complement)IBA
03/2022 - 12/2002
4ZincIBA
10/2020 - 01/2014
4Pneumococcal Vaccines (Pneumococcal Polysaccharide Vaccine)IBA
01/2019 - 06/2012
4Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2015 - 06/2007
3RaffinoseIBA
01/2022 - 01/2019
3LigandsIBA
01/2020 - 05/2007
3ThapsigarginIBA
12/2019 - 11/2009
3Carrier Proteins (Binding Protein)IBA
01/2016 - 07/2002
3pneumococcal surface protein AIBA
10/2015 - 07/2002
3AntibodiesIBA
09/2012 - 04/2002
2N-Acetylneuraminic Acid (Sialic Acid)IBA
03/2022 - 07/2009
2Biomarkers (Surrogate Marker)IBA
03/2022 - 01/2016
2N-glycolylneuraminic acidIBA
03/2022 - 01/2018
2Glucose (Dextrose)FDA LinkGeneric
01/2022 - 10/2019
2Peptides (Polypeptides)IBA
01/2022 - 12/2018
2CholesterolIBA
11/2021 - 06/2012
2Transcription Factors (Transcription Factor)IBA
10/2021 - 09/2014
2SugarsIBA
01/2021 - 01/2020
2ChemokinesIBA
01/2020 - 04/2011
2DisulfidesIBA
11/2019 - 01/2017
2Nonesterified Fatty Acids (NEFA)IBA
01/2019 - 01/2018
2Biological ProductsIBA
01/2017 - 01/2013
2Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
10/2015 - 11/2011
2Choline (Choline Chloride)IBA
10/2015 - 07/2002
2aluminum sulfate (alum)IBA
10/2015 - 01/2013
2Bortezomib (Velcade)FDA Link
05/2015 - 10/2010
2IronIBA
02/2013 - 10/2005
2flt3 ligand protein (flt3 ligand)IBA
12/2012 - 09/2007
2Molecular Chaperones (Chaperone, Molecular)IBA
09/2012 - 01/2011
2Neuraminidase (Sialidase)IBA
06/2011 - 07/2006
2OligosaccharidesIBA
05/2010 - 03/2006
2CC ChemokinesIBA
04/2009 - 05/2007
2Toll-Like Receptor 4IBA
10/2005 - 02/2003
2Bacterial ToxinsIBA
05/2005 - 07/2004
2Messenger RNA (mRNA)IBA
10/2003 - 07/2002
1Tumor Biomarkers (Tumor Markers)IBA
03/2022
1LectinsIBA
03/2022
1Sirolimus (Rapamycin)FDA Link
01/2022
1Mechanistic Target of Rapamycin Complex 1IBA
01/2022
1SterolsIBA
11/2021
1CarbohydratesIBA
01/2021
1Temozolomide (Temodar)FDA LinkGeneric
01/2021
1LipidsIBA
01/2021
1Fatty Acids (Saturated Fatty Acids)IBA
01/2021
1IgA-specific serine endopeptidaseIBA
01/2021

Therapy/Procedure

5Intraperitoneal Injections
03/2017 - 07/2004
4Drug Therapy (Chemotherapy)
10/2021 - 10/2015
4Therapeutics
12/2019 - 11/2011